Non-Invasive Prenatal Tests (NIPT)

SynsorBio offers One-Stop Solutions of NGS applications to our customers. SynsorBio XS240N and SynplStation 2400+ form an Automated Solution for sample preparation before sequencing. In addition, SynsorBio also provides different Bioinformatics Analysis Systems according to different NGS detection applications.

In the maternal blood, there is fetal cell free DNA (cfDNA). Non-Invasive Prenatal Tests (NIPT) are blood tests for pregnant women, with Next-generation sequencing (NGS) technology and Bioinformatics analysis, they give a near-diagnostic level of accuracy for the commonest chromosome problems in pregnancy ‒ trisomies 21, 18 and 13. The American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) endorse NIPT as having the highest detection rate and lowest false positive rate for the common aneuploidies regardless of maternal age or baseline risk, of all screening options.

Advantages of NIPT

NIPT based on the analysis of fetal cell-free DNA (cfDNA) in Maternal blood to provide information about fetal chromosomal abnormalities. The concentration of fetal cfDNA fragments plays a crucial role in the sensitivity and specificity of NIPT.

SynsorBio developed an optimized protocol, with which the concentration of fetal cfDNA fragments in the library has been nearly DOUBLED.